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Methotrexate 59-05-2 Antimetabolite Pharmaceutical Intermediate Research Oncology Use

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Methotrexate 59-05-2 Antimetabolite Pharmaceutical Intermediate Research Oncology Use

Brand Name:	Xuanming
Model Number:	59-05-2
MOQ:	1g
Price:	50USD
Packaging Details:	foil bag
Payment Terms:	T/T

Detail Information

Product Description

Detail Information

Place of Origin:

Jiangsu

Product Name:

Methotrexate

CAS Number:

59-05-2

Appearance:

Yellow To Orange Crystalline Powder

Purity:

≥ 98%

Melting Point:

195–203°C

Solubility:

Slightly Soluble In Water

Assay Method:

Heavy Metals:

≤ 10 Ppm

Supply Ability:

1000kg

Product Description

Methotrexate 59-05-2 Antimetabolite Pharmaceutical Intermediate Research Oncology Use

Product Overview

Methotrexate (CAS 59-05-2) is a folic acid antagonist belonging to the antimetabolite class. It is widely used in pharmaceutical research and biochemical studies due to its ability to inhibit dihydrofolate reductase, thereby affecting DNA synthesis and cell proliferation.

It is commonly applied in oncology research, autoimmune mechanism studies, and pharmaceutical formulation development.

Key Characteristics

Folic acid antagonist structure
High biological activity
Strong enzyme inhibition effect
Stable crystalline compound
Suitable pharmaceutical intermediate
High purity research grade
Well studied mechanism of action
Consistent chemical performance

Applications

Oncology research studies
Anticancer research systems
Autoimmune disease research
Pharmaceutical intermediate synthesis
Cell biology research systems
Clinical formulation development
Laboratory biochemical studies
Enzyme inhibition studies

Product Specifications

Item	Specification
Product Name	Methotrexate
CAS Number	59-05-2
Molecular Formula	C20H22N8O5
Molecular Weight	454.44 g/mol
Appearance	Yellow to orange crystalline powder
Purity	≥ 98%
Melting Point	195–203°C
Solubility	Slightly soluble in water
Assay Method	HPLC
Heavy Metals	≤ 10 ppm
Loss on Drying	≤ 0.5%

Physicochemical Properties

Methotrexate is a structural analogue of folic acid that competitively inhibits dihydrofolate reductase. This inhibition disrupts nucleotide synthesis and DNA replication, making it a key compound in biochemical and pharmaceutical research.

Advantages

Well-characterized mechanism of action
High research value in oncology
Stable crystalline structure
Suitable for laboratory use
Consistent analytical performance
Widely referenced in biochemical studies

Storage Conditions

Store in a tightly sealed container in a cool, dry place. Protect from light and moisture to maintain stability and chemical integrity.

Packaging Options

1 g / 10 g research vials
100 g / 500 g sealed foil bags
Custom bulk packaging available

Quality Control

Each batch is analyzed by HPLC for purity, moisture content, and impurity profile to ensure consistent quality suitable for research applications.

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15995072465

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Methotrexate 59-05-2 Antimetabolite Pharmaceutical Intermediate Research Oncology Use