Boc‑4‑iodo‑L‑phenylalanine 62129-44-6 for peptide synthesis off white crystalline powder

Boc‑4‑iodo‑L‑phenylalanine, also known as Boc‑Phe(4‑I)‑OH, belongs to protected unnatural aromatic amino acids. A tert butoxycarbonyl group attaches to the amino terminus, shielding the amine group and preventing undesired coupling during peptide assembly. The iodine atom on benzene para position provides distinctive heavy atom signature for analytical detection.

This compound maintains L configuration and shows strong resistance to racemization under regular handling. It exists as fine crystalline powder and keeps stable when kept away from moisture and strong light. Researchers choose this protected monomer to simplify controlled peptide chain assembly and build labelled molecular probes. It acts as a practical building block for biochemical exploration and custom peptide fragment preparation.

The material undergoes gradual decomposition upon heating before forming a clear melting point. It has limited solubility in water and dissolves readily in DMF, DCM and other common peptide synthesis solvents. Humid environment accelerates slow Boc cleavage and deiodination. Its hygroscopic level remains low under dry storage conditions.

The Boc protecting group can be selectively removed under acidic conditions without disrupting the carbon iodine bond if reaction parameters are well controlled. The heavy iodine substituent delivers strong scattering signal in crystallographic analysis and unique mass marker for tracing synthetic peptides. These traits make it different from ordinary Boc phenylalanine variants.

This protected amino acid is designed for incorporation in solid phase peptide synthesis. After assembly on resin, selective deprotection exposes the terminal amine for further chain elongation. The embedded iodine site supports site specific modification and bioconjugation. It enables targeted tracking in proteomics assays and helps examine peptide interaction with biological targets.

Common usage covers X ray crystallography sample preparation, labelled peptide probe fabrication and custom sequence construction for in vitro biochemical testing.

Conduct all operations inside ventilated space with protective eyewear and gloves. Avoid inhalation of fine powder dust. Keep apart from strong acid and oxidising agents which may trigger degradation and iodine release. Seal container tightly immediately after sampling. Do not store together with volatile amines. Treat residual waste according to local chemical disposal rules.