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(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research

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(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research

Brand Name:	Xuanming
Model Number:	CAS 877397-65-4
MOQ:	1 kg
Price:	5240-5250USD
Packaging Details:	drum
Payment Terms:	T/T

Detail Information

Product Description

Detail Information

Place of Origin:

China

CAS Number:

877397-65-4

Molecular Formula:

C₈H₇Cl₂FO

Molecular Weight:

209.045

Appearance:

Off-white Crystalline Powder

Available Purity:

98%, 99%

Density:

1.4 G/cm³

Supply Ability:

Product Description

(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research

Product Introduction

(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research

Core Specification Table(8 items)

Index	Data
CAS Number	877397-65-4
Molecular Formula	C₈H₇Cl₂FO
Molecular Weight	209.045
Appearance	Off-white crystalline powder
Melting Range	42–46 ℃
Boiling Point	261.3 ℃ (760 mmHg)
Available Purity	98%, 99%
Density	1.4 g/cm³

Core Product Properties

1. Pure S Chiral Configuration

This compound only contains S enantiomer without racemic mixtures. Optical rotation test data keeps consistent across different batches, and chiral structure will not convert to R configuration under sealed dark storage.

2. Uniform Crystal Morphology

Fine crystalline particles without caking or foreign impurities, dissolves evenly in common organic solvents to reduce experimental reaction errors.

3. Selective Solubility Trait

Slightly soluble in methanol, ethanol and DMSO; insoluble in water, alkane and solvents, matching solvent system for pharmaceutical chiral synthesis.

4. Reliable Thermal Stability

No racemization or molecular cracking below 100 ℃. Thermal decomposition only occurs when temperature exceeds 260 ℃, releasing halogen-containing by-products.

5. Active Hydroxyl Functionality

The chiral hydroxyl group supports esterification, substitution and cross-coupling reactions, acting as key unit to construct crizotinib molecular skeleton.

6. Strict Impurity Control

Moisture, single unknown impurity and halogen residue are limited within inspection thresholds for intermediates, fit for lab test and pilot scale-up preparation.

7. Anti-Oxidation Storage Stability

Chlorine and fluorine substitution strengthens molecular stability. Shelf life reaches 2 years under airtight cool environment with no obvious quality decline.

8. Stable Batch Consistency

Fixed element proportion and molecular composition for every batch, delivering steady conversion rate in downstream synthesis steps.

Application Scope

Essential synthetic precursor of crizotinib for non-small cell lung cancer targeted therapy
Raw material for asymmetric catalysis and chiral compound structural modification lab tests
Intermediate for developing new small-molecule kinase inhibitor

Storage & Handling Guidance

Short-term storage: 2–8 ℃, fully sealed and shaded environment
Long-term storage: -20 ℃ airtight container to extend service cycle
Isolate from strong oxidants, high-temperature heat sources and ultraviolet radiation
Reduce frequent opening of packaging to avoid moisture absorption and light-induced racemization

Physical Properties

Solid chiral aromatic alcohol under ambient temperature. Slightly soluble in methanol, insoluble in water. Crystalline structure maintains stable optical rotation under sealed storage.

Chemical Properties

No spontaneous decomposition at room temperature. Hydroxyl group supports esterification reaction. Single S configuration avoids racemic impurities during downstream synthesis. Thermal decomposition releases hydrogen halide under high heat.

Application Scope

Chiral building block for compound preparation, laboratory asymmetric synthesis research, fine chemical intermediate production.

Storage Guidance

Seal container tightly, place inside low temperature dry space, isolate from strong oxidants and direct sunlight exposure.

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(S)-1-(2,6-Dichloro-3-fluorophenyl) ethanol Intermediate for Pharma Research

Core Product Properties

1. Pure S Chiral Configuration

2. Uniform Crystal Morphology

3. Selective Solubility Trait

4. Reliable Thermal Stability

5. Active Hydroxyl Functionality

6. Strict Impurity Control

7. Anti-Oxidation Storage Stability

8. Stable Batch Consistency

Application Scope

Storage & Handling Guidance